Nuclear Receptor Signaling Atlas - Informational portal for researchers interested in nuclear receptor signaling. - http://www.nursa.org/
The RNAi Cure - A NOVA ScienceNOW science program by PBS feature the possible applications for RNAi therapy. Provides animations of key biological processes and mechanism of RNA Interference. - http://www.pbs.org/wgbh/nova/sciencenow/3210/02-cure.html
Genetic Diversity - Provides educational modules covering such parts of biology as genetics, cell biology, and gene expression. - http://genetics.nbii.gov
DBTGR - Database of Tunicate Gene Regulation - Gene expression database of tunicates. Provides the descriptions of 12 transcription factors and 140 promoters. - http://dbtgr.hgc.jp
CnidBase: Cnidarian Evolutionary Genomics Database - Cnidbase provides tools for researchers interested in studying gene expression of these organisms. Provides sequence BLAST tools, keyword search of genes and homologs, a literature scan, and several useful links. - http://cnidbase.bu.edu/
NANOPOLIS - Educational portal providing nanotechnology articles and multimedia courses in the multidisciplinary research areas. - http://www.nanopolis.net
RNAi Transfection Resource - Review of transfection techniques such as electroporation, denrimers and lipids that are used for transfection of DNA, RNA, and siRNA. Includes information on optimized cell type specific transfection systems. - http://cell-transfection.blogspot.com/
Ordway Research Institute - Not-for-profit corporation with a mission to translate basic science observations into therapeutics. Provides research services including quantitation of endogenous levels of microRNAs and mRNAs from experimental samples. Includes information on research - http://www.ordwayresearch.org
Journal of RNAi and Gene Silencing - Publishes peer-reviewed articles addressing the biology and application of RNA interference and gene silencing. Includes information about journal aims and scope, publication policies, and manuscript submission. Provides online access to journal articles. - http://www.libpubmedia.co.uk/RNAiJ/RNAiJHome.htm
Focus Areas: RNAi from Invitrogen - Educational and product support page. Includes RNAi overview, history, and research suggestions for gene silencing experiments. - http://www.invitrogen.com/content.cfm?pageid=10062
Second Annual Meeting of the Oligonucleotide Therapeutics Society - Yearly conference organized by New York Academy of Sciences. Scientists from industry and academia meet to discuss use of oligonucleotide-based gene-silencing techniques for development of innovative therapeutics. Includes information about conference reg - http://www.nyas.org/events/eventDetail.asp?eventID=5753&date=10/19/2006
RNAi Meeting: From Target Discovery and Validation to Therapeutic Development - CHI's Discovery on Target RNAi meeting organized by Cambridge Healthtech Institute at Boston, Massachusetts, October 25-26, 2006. Meeting provides overview of various aspects in RNA Interference (RNAi) research, ranging from in vitro and in vivo drug disc - http://www.discoveryontarget.com/06-RNAI.asp
Oligoengine - Oligonucleotide design software for applications such as RNAi, DNA methylation, antisense, and genome arrays. - http://www.oligoengine.com
RNAi Gateway - Web resource from BioMed Central. Provides RNA Interference (RNAi) research highlights, journal links, news, and meeting information. - http://www.biomedcentral.com/gateways/RNAi/
RNA Interference - Interactive online resource from Howard Hughes Medical Institute. Presents RNAi mechanism and overview of key scientific findings. - http://hhmi.org/biointeractive/rna/rnai/
Article on siRNA from Wikipedia - Describes small interfering RNA (siRNA) function, structure, use in research, and potential application for therapy. - http://en.wikipedia.org/wiki/Small_interfering_RNA
SI RNA - Small Interference RNA Resources - Online resource from Ion Channel Media Group. Provides news, publication links, and citations of the recent literature relevant to RNA Interference research. - http://www.si-rna.com
Transcriptional Gene Silencing - Mechanisms of TGS by Kevin Morris laboratory. Includes description of HIV research performed using lentiviral vector gene therapy and RNAi mediated gene silencing. - http://www.scripps.edu/mem/rheum/morris/tgs/
RNAi Therapeutics: How Likely, How Soon? - Review article from PLoS Biology journal. Describes mechanism of RNA Interference, potential applications towards therapeutics, and current problems associated with delivery. - http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0020028
The RNAi vs. HIV - Reviews the use of this therapy in fighting HIV. Includes mechanism, difficulties, terms, and featured experiments. - http://myweb.dal.ca/tbaptist/rnai/
RNAi Research and Therapeutics Conference - Meeting organized by GTCbio with main focus on RNA Interference. Purpose of the conference is to facilitate the exchange of biopharmaceutical and biomedical intelligence between industry leaders, academic and government organizations, and the financial co - http://gtcbio.com/confpage.asp?cid=21
Oligonucleotide Therapeutic Society - Society host conferences on academia and industry-based research and development of oligonucleotide therapeutics: RNAi, antisense, and others. Provides society overview, publication materials, meetings, and contact information. - http://www.myots.org/
InFocus RNAi Web Broadcast by Bio.com - RNAi Advances In 2005: Technologies And Applications. Bio.com provides an online RNAi technology-focused webcast, experts in the field discuss new insights into the regulation of gene expression by RNAi. Includes event description and downloadable webcast - http://www.bio.com/newsfeatures/infocus.jhtml?infocusId=500001&realmId=
Navigating Journey of Genome to Medicine - Review article on RNAi by International Herald Tribune. Provides an overview on RNA Interference discovery, current research efforts, and therapeutic potential. - http://www.iht.com/articles/2005/06/22/news/snturn.php
Article on RNAi by GNN - Online article describing gene silencing mechanism and how RNAi can be used for HIV treatment. - http://www.genomenewsnetwork.org/articles/06_02/hiv.shtml
Article on RNAi by HOPES - Online article describes basic mechanism of RNAi and how it can be applied for Huntington's disease treatment. - http://www.stanford.edu/group/hopes/treatmts/pbuildup/h2.html
A TV Show on RNAi by PBS - NOVA scienceNOW TV program describes RNAi as a major breakthrough in gene therapy with enormous medical promise. Provides basic overview of RNAi technology, current therapeutic approaches, and interview with the experts in the field. Includes 15-minutes T - http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html
Protein Lounge - Provides database that contains targets against mRNA sequences throughout a variety of organisms. Includes gene search option, and disease-specific siRNA genes. - http://www.proteinlounge.com/sirna_home.asp
RNAi Therapies by Nature Medicine Journal - Article on RNAi therapy potential describing advantages for novel drug discovery and safety concerns. - http://www.nature.com/news/2005/050221/pf/nm0305-243_pf.html
Drosophila RNAi Resource - Informational RNAi resource on studying drosophila genes and their roles in development by Society for Developmental Biology. - http://www.sdbonline.org/fly/aignfam/rnaistuf.htm
RNAi Resource at Macalester College - Informational resource, including RNAi mechanism, overview of current studies, and related research protocols. - http://www.macalester.edu/~montgomery/RNAi.html
Gene Silencing Mechanism - Animation of post transcriptional gene silencing or RNA Interference (RNAi) by Nature Reviews Genetics. - http://www.nature.com/nrg/journal/v2/n2/animation/nrg0201_110a_swf_MEDIA1.html
Cambridge Healthtech Institute - CHI organizes RNAi-related conferences throughout the US and Europe, including therapeutics, pharmaceutics, drug development, target discovery, and biodefense. Provides biotechnology news and conferences information. - http://www.healthtech.com/
SBS Conference - The Society for Biomolecular Screening holds a conference on high-throughput RNAi screening approach using siRNA/shRNA libraries on September 11-15, 2005. - http://www.sbsonline.org/sbscon/2005/index.php
Isis Pharmaceuticals Inc. - Discovers and develops drugs based upon antisense and RNAi technology. Focused on RNA as a therapeutic target. Includes overview of recent research and drug development approaches. - http://www.isispharm.com/
Cenix BioScience GmbH - Develops RNA-mediated Interference (RNAi) technology for the discovery of conventional therapeutics. Biological research data and company information is provided. - http://www.cenix-bioscience.com
TargetScan - Online software provided by MIT for prediction of microRNA targets. Provides research data and online software for microRNA target identification and analysis. - http://genes.mit.edu/targetscan/
RNAi Resource at Ambion - Online RNA Interference (RNAi) resource. Provide scientific and technical support, information on microRNA and small interfering RNA application in gene expression research. - http://www.ambion.com/techlib/resources/RNAi/
The microRNA Registry - Online resource provides a service for the assignment of miRNA gene names. Provides searchable database of published miRNA sequences. Includes data and research application information. - http://www.sanger.ac.uk/Software/Rfam/mirna/
RNA Interference at Journal Nature - Focus RNA Interference - online resource publishing recent advances in RNAi field, and novel applications in Nature Cell Biology and Nature Reviews. - http://www.nature.com/focus/rnai/
Pharmaceutical Discovery - Peer-review online journal publishing articles on recent advances in life sciences research and drug discovery. Includes RNAi related news, overview of new technology, and research articles. - http://www.pharmaceuticaldiscovery.com/
RNAi BioForum - Online forum for siRNA, microRNA and RNAi methods discussion. - http://www.protocol-online.org/forums/index.php?showforum=21
Wikipedia Article on RNAi - Online article describing the basics of RNA Interference (RNAi) mechanism. - http://en.wikipedia.org/wiki/RNA_interference
RNAi Database - Contains all siRNA from C. elegans including assay, resulting phenotypes, dsRNA target location. Database provides Gene/Protein or Phenotype search options. - http://www.rnai.org/
RNAi News - Online resource for scientists, researchers, technologists, and executives engaged in RNA Interference, functional genomics, and drug discovery. Offers industry news, product reviews, and meetings information. - http://www.rnainews.com
RNAi Mechanism Animation by Journal Nature - An animation from Nature Publishing Group on the mechanism of RNA Interference (RNAi). - http://www.nature.com/focus/rnai/animations
RNAi.net - Online resource offering information RNA interference and related issues: news, interviews, articles, techniques. - http://www.rnai.net
The RNAi Web - Online resource for RNA Interference (RNAi) technology. Offers overview of technology, references, and links on other RNAi-related web resources. - http://www.rnaiweb.com/