Puerto Rico Water Resources and Environmental Research Institute
- Sponsoring a substantial number of research projects, supported jointly by federal and University of Puerto Rico's funds.
- http://www.ece.uprm.edu/rumhp/prwrri/

Center for Molecular and Behavioral Neuroscience
- Universidad Central del Caribe. Inter institutional research center whose goal is to promote and facilitate neuroscience research.
- http://www.cmbn.org/

Puerto Rico Tsunami Warning and Mitigation Program
- Project for the preparation and supply of flooding and evacuation maps to assess the vulnerability of all coastal areas.
- http://poseidon.uprm.edu

Tropical Agriculture Research Station
- Located in Mayaguez, the purpose of this project is to conduct fundamental research on tropical plants and crops.
- http://www.ars-grin.gov/ars/SoAtlantic/Mayaguez/mayaguez.html

Institute of Tropical Forestry
- Part of the United States Department of Agriculture Forest Service and dedicated to the study of tropical forestry on an international level.
- http://www.fs.fed.us/global/iitf/welcome.html

Arecibo Observatory
- Site of the world's largest single-dish radio telescope, and recognized as one of the most important centers for research in radio astronomy, planetary radar and terrestrial aeronomy.
- http://www.naic.edu/