KoLBot - A Perl class that alows interaction with the Kingdom of Loathing. - http://www.brandybuck.com/kolbot/
Helper Window to Increase Loathing Efficiency - Discussion thread with instructions on how to create customized pages with shortcuts for various KoL actions. - http://www.munk.org/w23/viewtopic.php?t=26
KwiKoL - Java library for the Kingdom of Loathing, designed for those who wish to program custom interfaces to the game. Downloadable source and executable. - http://sourceforge.net/projects/kwikol
KoLmelion - Windows desktop interface to the Kingdom of Loathing, which automates multiple adventures in a single location, inventory, and familiar management. Downloadable source and executable. - http://kolmelion.sourceforge.net/
KoLmafia - Java client which automates repetitive game tasks, such as inventory management and mall shopping. Downloadable source code and JAR binary. - http://kolmafia.sourceforge.net/
KoL CLI - Simple command-line interface for Kingdom of Loathing, using Perl and curl. - http://www.subjunctive.net/kol/kolcli.html