mxODBC
- A DB-API 2.0 compliant ODBC Interface for Python. Available for Windows, Unix and Mac OS X. [Commercial]
- http://www.egenix.com/products/python/mxODBC/

PoPy
- A PostgreSQL driver for Python. [Open Source, GPL]
- http://www.zope.org/Members/tm/

Sybase module for Python
- A Python interface to the Sybase relational database system. [Open Source, BSD-like]
- http://python-sybase.sourceforge.net//

pysqlite
- A Python interface using the SQLite embedded relational database engine that conforms to the Python Database API Specification 2.0. [Open Source, zlib/libpng license]
- http://initd.org/tracker/pysqlite

pg8000
- A pure Python interface to the PostgreSQL database engine. [Open Source, BSD-like]
- http://pybrary.net/pg8000/

cx_Oracle
- Oracle 8i interface developed by Computronix. [Open Source, BSD-like]
- http://www.python.net/crew/atuining/cx_Oracle/

pymssql
- A fast MS SQL Server client library for Python directly using C API instead of ODBC. Also supports UN*X platforms with FreeTDS. [Open Source, LGPL]
- http://pymssql.sourceforge.net/

bpgsql
- A barebones PostgreSQL client written in pure Python. [Open Source, MIT]
- http://barryp.org/software/bpgsql/

pgasync
- A PostgreSQL client library for Python with special support for Twisted. [Open Source, BSD]
- http://jamwt.com/pgasync/

pyodbc
- An implementation of the Python Database API Specification v2.0 for ODBC on Microsoft Windows. [Open Source, MIT license]
- http://pyodbc.sourceforge.net/

zxJDBC
- Database connectivity in Jython (Python on the Java platform). [Open Source, Python license]
- http://www.ziclix.com/zxjdbc/

SQL Relay
- Persistent database connection pooling, proxying and load balancing system for Unix with a Python API. [Open Source]
- http://sourceforge.net/projects/sqlrelay/

SAP DB
- An interface to the SAP DB database. [Open Source, LGPL]
- http://www.sapdb.org/sap_db_program.htm

pyPgSQL
- A Python DB-API 2.0 compliant interface to a PostgreSQL (v7.0 and later) database. [Open Source, BSD-like]
- http://pypgsql.sourceforge.net/

PyGreSQL
- PostgreSQL module for Python. [Open Source, BSD-like]
- http://www.druid.net/pygresql/

psycopg
- A PostgreSQL database adapter for Python. [Open Source, GPL]
- http://initd.org/projects/psycopg1

ODBTPAPI
- A Python DB-API 2 module for accessing Windows databases like SQL Server, Access, Visual FoxPro or any other database for which there exists a Windows ODBC driver. This module uses the efficient Open Database Transport Protocol. [Open Source, LGPL]
- http://www.benjiyork.com/odbtp.html

MySQLdb
- Python interface to MySQL databases. [Open Source, Python License/GPL]
- http://sourceforge.net/projects/mysql-python/

KInterbasDB
- Python module for interfacing Interbase databases. [Open Source, BSD-like]
- http://kinterbasdb.sourceforge.net/

Ingres interface
- A Python database API 2.0 conforming CA Ingres module.
- http://www.informatik.uni-rostock.de/~hme/software/

DCOracle2
- A Python DB API 2.0 adapter for Oracle 8. [Open Source, ZPL]
- http://www.zope.org/Members/matt/dco2

DCOracle
- Python DB-API interface to Oracle 7 and 8 databases. [Open Source, BSD-like]
- http://www.zope.org/Products/DCOracle

ADODBAPI
- A DB-API 2.0 module for accessing data sources via Micrsosoft ADO. [Open Source, LGPL]
- http://adodbapi.sourceforge.net/