In The Puddle
- Semi-reality webcomic by Cique Johnson, about bisexual, lesbian and straight young adults in Philadelphia - starring artist and pastafarian Cique, her guy, and pet bat.
- http://www.inthepuddle.com

In the Bleachers
- Steve Moore's syndicated humor cartoon about sports.
- http://www.gocomics.com/inthebleachers/

In Real Life
- Following the adventures of Mario, Mega Man, and Link when they are sucked out of the Super NES.
- http://saywhatpb.comicgenesis.com/

Idiom Syndrome
- A photo-webcomic with random humour for the most part.
- http://idiomsyndrome.comicgenesis.com/

Ignaki
- A collection of cartoons about food, computers, art; translated into English. By Ignacio Lafferriere.
- http://www.ignaki.com/eng.htm

The Invisible Life of Poet
- Social commentary through the eyes of a child. By Christopher Wilson.
- http://www.lifeofpoet.com/

Inepto.com
- Lampoons ineptitude at all levels of society, from customer service to CEOs and politicians.
- http://www.inepto.com/

I'm Blue
- Highlights the trials, tribulations and comedy of the main character Blue Veers, and her friends Celia, Derec, Tyger, Max, and Duo.
- http://www.blue-comic.com/

Isk
- A web comic about a small tormented child.
- http://users.tpg.com.au/rocket48/isk

Irregular Webcomic!
- Lego and gaming photo comics by David Morgan-Mar.
- http://www.irregularwebcomic.net/

Intershadows
- Features an archive of the title, a gallery of sketches and illustrations, and the series Coolville. By Kathleen Jacques.
- http://www.intershadows.com/

Is This Tomorrow?
- Features collections, a history, and archives of various strips. Created by Kelly Shane & Woody Compton.
- http://www.isthistomorrow.com/

Interns
- Features three interns as they work at a prominent comic book publisher. Includes character bios.
- http://www.internsthecomic.com/

The Imp
- A humor strip about hell, by Jose Arroyo and Robin Reed.
- http://www.barstowproductions.com

Inktank.com
- Two strips: Angst Technology, about a game development company, and Weak-end Warriors, about paintball.
- http://www.inktank.com

Insane Add-a-Panel
- Add a panel to this comic. An always changing comic.
- http://www.zerotv.com/addapanel/panel.cfm?pt=multi

Isometric
- A comic strip drawn entirely with isometric perspective cubes.
- http://isometric.spaceninja.com

The Infirm
- Humor comic about a first-year associate attorney.
- http://www.baywalk.com/cartoons/infirm.htm

Ink
- A comic strip about a full-time father/part-time cartoonist and his family. By Jason Milfred.
- http://www.inkography.com

It Could Happen
- A comic strip which takes a unique and entertaining look into the life of a home schooling family. By Gail Anne.
- http://www.itcouldhappen.com/

Innies and Outties
- Funny comic strip about two latchkey kids imagining their way through the enchanted land of suburbia. By Leonard Cachola.
- http://www.inniesandoutties.com

Intelligent Humor
- Offbeat comic, also known as "Big Meaty Chunks", by Chris Williams. Collected by Steven Dengler of Xenon Labs.
- http://www.xe.net/inthumor/